[HTML][HTML] T-cell factors as transcriptional inhibitors: activities and regulations in vertebrate head development

J Bou-Rouphael, BC Durand - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
… describes the activities and regulatory modes of TCF/LEF as transcriptional repressors, with
… of TCF7L1 repressor activities in both SO formation, and forebrain progenitor proliferation. …

[HTML][HTML] Rspo2 inhibits TCF3 phosphorylation to antagonize Wnt signaling during vertebrate anteroposterior axis specification

AH Reis, SY Sokol - Scientific reports, 2021 - nature.com
formation 38,39 , suggesting that they could be responsible for the observed Rspo2 activity.
… is predicted to be rescued by a constitutive TCF3 repressor that does not bind β-catenin (∆…

[HTML][HTML] Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors

M He, R Zhang, S Jiao, F Zhang, D Ye, H Wang… - PLoS …, 2020 - journals.plos.org
repressor of maternal β-catenin signaling to safeguard the embryo against hyperactivation of
maternal β-catenin activity … -catenin activity is crucial for proper dorsoventral axis formation. …

[HTML][HTML] Zebrafish as an animal model for biomedical research

TY Choi, TI Choi, YR Lee, SK Choe… - Experimental & Molecular …, 2021 - nature.com
… signaling pathway is essential in head/brain formation and patterning in vertebrate animals.
… Whole-body metabolism is the sum of all metabolic activity of individual organs that …

[HTML][HTML] Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis

SJ Pradhan, PC Reddy, M Smutny, A Sharma… - Nature …, 2021 - nature.com
… into mechanisms underlying the temporal activity of Satb2. … craniofacial development and
bone formation in mammals, … Satb2 acts as a transcriptional repressor of the same group …

Negative regulation of IL-8 in human astrocytes depends on β-catenin while positive regulation is mediated by TCFs/LEF/ATF2 interaction

KRF Robinson, SD Narasipura, J Wallace, EM Ritz… - Cytokine, 2020 - Elsevier
… factors, displacing co-repressors such as transducing-like … as either an activator or repressor
of transcription, depending … relevant to its basal and inducible activity, we performed site-…

Cilia regulate meiotic recombination in zebrafish

H Xie, X Wang, M Jin, L Li, J Zhu, Y Kang… - Journal of Molecular …, 2022 - academic.oup.com
… Meiosis is essential for evolution and genetic diversity in … Here, we reported an unexpected
and critical role of cilia … break repair, reduced crossover formation, and increased germ cell …

[HTML][HTML] β-Catenin and TCFs/LEF signaling discordantly regulate IL-6 expression in astrocytes

KRF Robinson, SD Narasipura, J Wallace… - Cell Communication and …, 2020 - Springer
… TCF1 can act as either a transcriptional activator or repressor, depending on cell and tissue
… Here, we show that β-catenin inhibits IL-6 promoter activity while also inducing NF-κB and C/…

pVHL regulates protein stability of TCF/LEF transcription factor family via ubiquitin-independent proteasomal degradation

C Wang, X Rong, H Zhang, B Wang, Y Bai, Y Liu, L Lu… - bioRxiv, 2021 - biorxiv.org
… expression by recruiting co-repressors or to activate target … conserved lysine residues in
several vertebrate TCF/LEF proteins … in directing dorsoventral or anteroposterior axis formation. …

Characterization of an eye field-like state during optic vesicle organoid development

LJ Owen, J Rainger, H Bengani, F Kilanowski… - …, 2023 - journals.biologists.com
Vertebrate eye development begins with the formation of the … -accessibility, associated with
key TFs, changes at individual … – enhancers and repressors) required for the differentiation …